Disorders of platelet number and/or function often occur in acute and chronic systemic diseases. As our understanding of the dynamic repertoire of platelets increases, new and exciting discoveries with regards to the biological functions of platelets in disease are being made. This session will focus on the role of platelets during human infectious, inflammatory, and thrombotic diseases. Particular emphasis will be placed on the clinical implications of dysregulated platelet functions during systemic disease.
Dr. Lambert will discuss how two common and morbid conditions, renal and liver disease, alter platelet number and function. She will review the impact of thrombocytopenia on bleeding complications in patients with these disorders. She will also highlight established and emerging data extending our understanding of how alterations in platelet function impact the course of these diseases.
Dr. Rondina will summarize the incidence, mechanisms, and clinical outcomes in septic patients with thrombocytopenia. He will also discuss recent findings whereby systemic infections induce key alterations in platelet functions, contributing to injurious host responses and adverse clinical outcomes.
Dr. Arepally will discuss recent developments in the pathophysiology, presentation, and emerging therapies for the management of heparin-induced thrombocytopenia. She will highlight recent progress in our understanding the pathogenesis of this pro-thrombotic condition, based on investigations of the PF4/heparin antigenic complex and role of inflammatory mediators.