This sickle cell disease education session will focus on three topics that clinicians are commonly addressing in their daily practice.
The first presentation- Dr. Jo Howard will focus on when and how to transfusion individuals with sickle cell disease with a focus on non-neurological complications, including pregnancy, the pre-operative setting, acute chest syndrome, multiple episodes of acute vaso-occlusive pain episodes unresponsive hydroxyurea therapy.
The second presentation- Dr. Michael R. DeBaun will emphasize optimal management of individuals with neurological complications in the absence of evidence from randomized controlled trials. Specific topics will include decision making heuristic that will facilitate management in the setting of uncertainty, including treatment of:Four common neurological problems and strategies for management in children with and adults with sickle cell disease will be discussed: 1) secondary stroke prevention in high income countries; 2) primary stroke prevention in low and middle income countries; 3) poor academic performance in students; and 4) cognitive disability in adults.
The third presentation- Dr. Theodore Wun will include a discussion on the increasing evidence that activation of the coagulation system contributes to the pathophysiology of the common complications of sickle cell disease. In addition, new data on incident venous thromboembolism (deep venous thrombosis and pulmonary embolism) will be presented and proposition that sickle cell disease represents an inherited thrombophilia with implications for the duration of anticoagulation.
Michael DeBaun, MD
Jo Howard, MD, Bchir
Ted Wun, MD
Active, International, Emeritus, and Honorary Members
Associate, International Associate, Student, and Resident Members