Microparticles and Exosomes: Ready for the Clinic?
Extracellular vesicles (EVs) are cell-derived vesicles that circulate in blood at high concentrations and may be intimately involved in the pathogenesis of a broad array of vascular disorders. This session will provide an overview of the biology and measurement of EVs, with a focus on the ability of EVs to carry and transfer microRNA between cells and organs, how this property may be used to define new biomarkers and improve the understanding of vascular pathophysiology.
Dr. Francoise Dignat-George will discuss the diversity of EV origins and mechanisms of formation, as well as the impact of this diversity on EV composition and biological roles. She will also discuss the methods used to measure EVs in clinical samples, with a specific focus on standardization and relevance of EVs as emerging biomarkers in disease.
Dr. Jason Fish will present recent work focused on the contribution of circulating microRNAs to cardiovascular disease performed using animal models and human clinical samples. He will also describe the development of high throughput methodologies to measure the microRNA content of EVs and gene regulatory networks that are impacted by transferred microRNAs.
Dr. Louise Laurent will discuss the potential utility of microRNAs within EVs and other extracellular compartments as biomarkers for preeclampsia and other related conditions. She will also provide an overview of the promises and challenges in developing extracellular RNA isolation and analysis methods for clinical applications.
Jason Fish, PhD
Louise Laurent, MD/PhD
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