What's New in the Diagnosis and Management of von Willebrand Disease?
Although von Willebrand disease (VWD) is the most common inherited bleeding disorder, diagnosis and management of patients with VWD continues to present challenges. This session will offer clinical insights into the new diagnostic methods to identify VWD subtypes and advances in both treatment options and perioperative management of patients with VWD.
Dr. Sandra Haberichter will discuss advances in the diagnosis of von Willebrand disease. The central role of bleeding assessment tools in quantification of historical bleeding symptoms will be reviewed. The evolution of platelet-dependent assays of von Willebrand factor (VWF) function and the role of new assays in identification of VWD subtype will be highlighted. The utility of genetic testing in different VWD subtypes will be reviewed.
Dr. Pier Mannucci will summarize the most recent clinical advances in treatment of patients with VWD. The rationale and determinants of therapeutic efficacy, laboratory monitoring of treatment, and new therapeutic options for treatment will be outlined. Dr. Mannucci will address the critical issue of gastrointestinal bleeding in VWD patients and discuss optimal management strategies for this condition.
Dr. Michelle Lavin will discuss the unique clinical challenge associated with the surgical management of patients with VWD. Perioperative risk assessment, surgery in the era of recombinant VWF and the risks of Factor VIII accumulation will be reviewed in this case-based discussion of perioperative management.
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