Spoiled for Choice: Donor Selection for Allogeneic Stem Cell Transplantation
Dr. Leo Luznik will discuss recent emergence of haploidentical transplantation as a viable option for patients with hematologic malignancies in need of allogeneic stem cell transplant. He will summarize recent wealth of clinical data utilizing haplo HSCT with modern GVHD prevention strategies and how to integrate them in clinical decision making. Recent biological advances on the biology of relapse and integration of novel agents after haplo HSCT to deal with disease recurrence will be also discussed.
Dr. Annalisa Ruggeri will review recent expirence and state of the art in the field of allogeneic stem cell transplantation using cord blood. She will review recent data from large registries summarizing outcomes for adult and pediatric patients receiving cord blood transplant for patients with hematological malignancies and non-malignant hematological disorders. The emerging results with new strategies for ex vivo expansion of cord blood and advantages associated with this approach will be also reviewed.
Dr. Katharina Fleischauer will summarize recent clinical advances using unrelated donors. She will summarize the available clinical evidence and discuss optimal selection of matched unrelated donors. New insights in the role of functional HLA matching in unrelated donor selection will be also presented including the relevant biology-driven algorithms.
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