New Diagnostic and Treatment Strategies for Antiphospholipid Syndrome
The antiphospholipid syndrome (APS) is an autoimmune disorder that can result in venous and arterial thrombosis and pregnancy complications. A catastrophic form of APS can present as a thrombotic microangiopathy affecting multiple organ systems. APS continues to be particularly challenging to diagnose, monitor and treat because its mechanistic basis is still being elucidated. Nevertheless, our APS patients require the best available treatments even before the final answers are in. This session will focus upon the progress which has been achieved in diagnosing and treating APS, including the potential of non-anticoagulant therapies.
Dr. Michelle Petri will discuss advances and refinements of diagnostic assays for APS. She will also review the contribution of complementopathies to the clinical manifestations of CAPS, and consider the currently available scoring systems for assessing the thrombotic risks to these patients.
Dr. Ware D. Branch will review the clinical and laboratory aspects of obstetric APS and also the current controversies regarding these. He will also discuss how clinical and laboratory features may be used to stratify the risks of adverse pregnancy outcomes in women with APS, and review the current evidence on treatment of obstetric APS.
Dr. Doruk Erkan will address the spectrum of APS-related clinical manifestations. He will also discuss a wide variety of potential immunosuppressive approaches for treating the microvascular and non-thrombotic manifestations of non-obstetric APS for which traditional antithrombotic therapies tend to be ineffective.
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